| ncRNA name | hsa-miR-181a |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell line Y79 |
| Methods | MTT assay, qRT-PCR, xenograft |
| Expression pattern | associated |
| Functional description | Gene analysis shows that miR-181a decreases the expression of anti-proliferative gene MAPK1 and anti-apoptotic gene Bcl-2, but significantly increased the expression of pro-apoptotic gene BAX. Melphalan and miR-181a have a complementary effect in reducing the viability of cultured Rb cells and decreasing Rb cell counts in an in-vivo xenograft Rb model in rats. |
| PubMed ID | 30776396 |
| Year | 2019 |
| Title | Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma. |
| Drug-related ncRNA | YES (melphalan) |
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