| ncRNA name | hsa-miR-146a |
| ncRNA Category | miRNA |
| Disease name | primary Sjögren's syndrome (pSS) |
| Species | Homo sapiens |
| Tissues/Cell_line | peripheral blood mononuclear cells (PBMCs); human monocytes line THP-1 |
| Methods | qRT-PCR, in situ hybridization, transfection, flow cytometry, transwell assay |
| Expression pattern | up-regulated |
| Functional description | Functional analysis revealed roles for miR-146a in increasing phagocytic activity and suppressing inflammatory cytokine production while migration, nitric oxide production and expression of antigen-presenting/costimulatory molecules are not affected in human monocytic THP-1 cells. |
| PubMed ID | 21469088 |
| Year | 2011 |
| Title | Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity. |
| Drug-related ncRNA | NO |
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