| ncRNA name | hsa-let-7b |
| ncRNA Category | miRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell lines OCM1 and OM431 |
| Methods | transfection, Western blot, CCK-8 assay, colony formation assay, qRT-PCR |
| Expression pattern | down-regulated |
| Functional description | The radioresistant UM cell lines OM431 and OCM1 were selected and exposed to irradiation, and let-7b was found to be downregulated after exposure. Let-7b overexpression can in turn downregulate cyclin D1 expression and enhance the radiosensitivity of UM through cell cycle arrest. |
| PubMed ID | 25588203 |
| Year | 2015 |
| Title | Let-7b overexpression leads to increased radiosensitivity of uveal melanoma cells. |
| Drug-related ncRNA | NO |
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