| ncRNA name | SPARC siRNA |
| ncRNA Category | siRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | human UM cell lines SP6.5, MKTBR and OCM-1; transformed human melanocyte cell line UW-1 |
| Methods | siRNA transfection, qPCR, proliferation assay, immunocytochemistry |
| Expression pattern | associated |
| Functional description | All cases of human uveal melanoma demonstrated positive staining for SPARC as did all primary and metastatic tumors from the xenograft model. The cell lines transfected with SPARC siRNA showed a significant decrease in proliferation compared to controls. |
| PubMed ID | 19661316 |
| Year | 2009 |
| Title | SPARC is expressed in human uveal melanoma and its abrogation reduces tumor cell proliferation. |
| Drug-related ncRNA | NO |
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