| ncRNA name | FTX |
| ncRNA Category | lncRNA |
| ID | 100302692 |
| Ensembl | ENSG00000230590 |
| Synonyms | FLJ33139; LINC00182; MIR374AHG; NCRNA00182 |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell lines MUM2B, 92.1, OCM1, OCM1A, OM431 and SP6.5; human embryonic kidney cell line HEK293T; RPE cell line ARPE19; female uveal tissue cell line FPC1 |
| Methods | RT-PCR, qRT-PCR, transwell assay, xenograft, microarray, RNA FISH, ChOP, CHIP |
| Expression pattern | down-regulated |
| Functional description | XIST lncRNA serves as a potential target of CANT1, and JPX or FTX lncRNA subsequently serves as a contextual hinge to activate a novel CANT1-JPX/FTX-XIST long non-coding (lncing) pathway in UM. CANT1 triggers the expression of JPX and FTX by directly binding to their promoters and promoting H3K4 methylation. |
| PubMed ID | 28330694 |
| Year | 2017 |
| Title | CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.