| ncRNA name | Gucy2e shRNA |
| ncRNA Category | shRNA |
| Disease name | retinitis pigmentosa (RP) |
| Species | Mus musculus |
| Tissues/Cell_line | retinas |
| Methods | shRNA knockdown, H&E staining, immunoblot, ERG |
| Expression pattern | associated |
| Functional description | We tested a novel combination therapy using bipartite lentiviral vectors designed to both introduce wild-type PDE6β expression and knockdown GUCY2E or CNGA1. In Pde6b(H620Q) mutants, we observe rescue of photoreceptor function and an increase in photoreceptor rows as compared with untreated controls. |
| PubMed ID | 21885480 |
| Year | 2011 |
| Title | Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa. |
| Drug-related ncRNA | NA |
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