| ncRNA name | PTN siRNA |
| ncRNA Category | siRNA |
| Disease name | proliferative vitreoretinopathy (PVR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | immunofluorescence, siRNA transfection, CCK-8 assay, transwell assay, qPCR, Western blot, immunocytochemistry |
| Expression pattern | associated |
| Functional description | PTN knockdown attenuated the TGF-β1-induced migration, proliferation, cytoskeletal rearrangement, and expression of EMT markers such as α-SMA and fibronectin in the ARPE-19 cells, and these effects may have been mediated through p38 MAPK signaling pathway activation. |
| PubMed ID | 28083679 |
| Year | 2017 |
| Title | The effects of pleiotrophin in proliferative vitreoretinopathy. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.