| ncRNA name | RhoA shRNA |
| ncRNA Category | shRNA |
| Disease name | optic nerve injury |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas, optic nerves |
| Methods | Western blot, shRNA injection, histology and immunohistochemistry |
| Expression pattern | associated |
| Functional description | AAV-RhoA shRNA decreased RhoA expression levels and promoted neurite outgrowth in vitro. In the ONC model, AAV-RhoA shRNA by itself had only weak beneficial effects on RGC axon regeneration. However, when combined with AAV-CNTF, AAV-RhoA shRNA significantly improved the therapeutic effect of AAV-CNTF on axon regeneration by nearly two fold. |
| PubMed ID | 28017835 |
| Year | 2017 |
| Title | AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration. |
| Drug-related ncRNA | NA |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.