| ncRNA name | hsa-miR-377 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | transfection, CCK-8 assay, cell cycle analysis, transwell assay, wound healing assay, tube formation assay, ELISA, qRT‑PCR, luciferase reporter assay, Western blot |
| Expression pattern | up-regulated |
| Functional description | miR-377 was confirmed to directly decrease target SIRT1 gene, further aggravated proliferation, cell cycle transition, migration and angiogenesis, pro-inflammatory molecules release induced by high glucose and hypoxia in vitro. |
| PubMed ID | 30706373 |
| Year | 2019 |
| Title | Down-regulation of miR-377 suppresses high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells by direct up-regulation of target gene SIRT1. |
| Drug-related ncRNA | NO |
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