| ncRNA name | FasL siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | MMP assay, apoptosis assay, MTT assay, qPCR, siRNA transfection, Western blot |
| Expression pattern | associated |
| Functional description | Advanced glycation end-products (AGEs) are extremely accumulated in the retinal vascular and epithelial cells of diabetes mellitus (DM) patients, particularly with diabetic retinopathy (DR). The siRNA-mediated knockdown of Fas/FasL inhibited the AGE-BSA-induced apoptosis. |
| PubMed ID | 26479732 |
| Year | 2016 |
| Title | Advanced glycation end-product (AGE) induces apoptosis in human retinal ARPE-19 cells via promoting mitochondrial dysfunction and activating the Fas-FasL signaling. |
| Drug-related ncRNA | NO |
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