| ncRNA name | OGT siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal microvascular endothelial cells (HRECs) |
| Methods | Western blot, siRNA transfection, qRT-PCR, flow cytometry |
| Expression pattern | associated |
| Functional description | The reduction of O-GlcNAcylation following infection with OGT siRNA, exacerbated the production of ROS and decreased the expression of antioxidant genes. Treatment with PUGNAc reduced glyoxal-induced cell apoptosis and transfection with OGT siRNA increased HREC apoptosis. |
| PubMed ID | 26311324 |
| Year | 2015 |
| Title | The augmentation of O-GlcNAcylation reduces glyoxal-induced cell injury by attenuating oxidative stress in human retinal microvascular endothelial cells. |
| Drug-related ncRNA | NO |
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