| ncRNA name | IGFBP-3 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (RECs) |
| Methods | siRNA transfection, Western blot |
| Expression pattern | associated |
| Functional description | Compound 49b, a novel β-adrenergic receptor agonist, is protective in a type 1 diabetic rat model. Compound 49b was not able to improve b-wave amplitudes and oscillatory potentials when IGFBP-3 was knocked down with siRNA, suggesting that Compound 49b regulates retinal function through restoration of IGFBP-3 levels in diabetes. |
| PubMed ID | 26115368 |
| Year | 2015 |
| Title | Beta-adrenergic receptor agonist decreases VEGF levels through altered eNOS and PKC signaling in diabetic retina. |
| Drug-related ncRNA | NO |
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