| ncRNA name | AKR1B1 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | siRNA transfection, Western blot |
| Expression pattern | associated |
| Functional description | AR is an enzyme that contributes to cellular stress by production of reactive oxygen species (ROS) under high glucose conditions. A marked decrease in cell viability (from 100% to 78%) following long-term exposure (4 days) of RPE cells to high glucose (HG) was largely prevented by siRNA-mediated knockdown of AR gene expression (from 79% to 97%). |
| PubMed ID | 25451566 |
| Year | 2015 |
| Title | Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. |
| Drug-related ncRNA | NO |
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