| ncRNA name | GPR91 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Mus musculus |
| Tissues/Cell_line | retinal ganglion cell line RGC-5 |
| Methods | shRNA knockdown, qRT-PCR, Western blot, immunofluorescence, ELISA, CCK-8 assay, transwell assay |
| Expression pattern | associated |
| Functional description | The siRNA-mediated knockdown of GPR91 was also found to inhibit the proliferation of RF/6A cells in high glucose-stimulated or succinate-stimulated conditioned media. However, the siRNA-mediated knockdown of GPR91 suppressed the migration of RF/6A cells incubated with moderate levels of glucose. |
| PubMed ID | 23379999 |
| Year | 2013 |
| Title | Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91. |
| Drug-related ncRNA | NO |
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