| ncRNA name | hsa-miR-23b-3p |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | microarray, qRT-PCR, luciferase reporter assay, Chromatin immunoprecipitation (CHIP), in situ hybridisation |
| Expression pattern | up-regulated |
| Functional description | High glucose increased miR-23b-3p expression, even after the return to normal glucose. Luciferase assays identified SIRT1 as a target mRNA of miR-23b-3p. Reduced miR-23b-3p expression inhibited Ac-NF-κB expression by rescuing SIRT1 expression and also relieved the effect of metabolic memory induced by high glucose in HRECs. |
| PubMed ID | 26687158 |
| Year | 2016 |
| Title | miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway. |
| Drug-related ncRNA | NO |
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