| ncRNA name | hsa-miR-2113 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human Müller cell line MIO-M1 |
| Methods | qPCR, Western blot, immunouorescent staining |
| Expression pattern | down-regulated |
| Functional description | HG-increased MMP-2 and MMP-9 and HG-decreased TIMP-2 in Müller cells. HG up-regulates Zeb1 and lncRNA RP11-982M15.8, and down-regulates miR-2113, and Rg1 inhibits these effects of HG. Both inhibition of miR-2113 and over-expression of RP11-982M15.8 significantly restored the HG induced mesenchymal activasion. |
| PubMed ID | 29654764 |
| Year | 2018 |
| Title | Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway. |
| Drug-related ncRNA | YES (Ginsenoside Rg1) |
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