| ncRNA name | CRYAA siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs) |
| Methods | siRNA transfection, qRT-PCR, ELISA, flow cytometry, Western blot |
| Expression pattern | associated |
| Functional description | The CRYAA siRNA not only induced HUVEC apoptosis but also inhibited exogenous and endogenous VEGF-induced cell activities, including proliferation, migration, and tube formation. In addition, CRYAA knockout led to increased levels of cleaved caspase-9 and caspase-3. |
| PubMed ID | 25574047 |
| Year | 2015 |
| Title | Knockout of αA-crystallin inhibits ocular neovascularization. |
| Drug-related ncRNA | NO |
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