| ncRNA name | HO-1 siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | RPE cell line ARPE-19 |
| Methods | siRNA transfection, semi-qRT–PCR, Western blot, cell proliferation assay, migration assay, tube formation assay |
| Expression pattern | associated |
| Functional description | Knockdown of HO-1 expression and inhibition of HO-1 activity resulted in potent reduction of the expression of vascular endothelial growth factor (VEGF) under hypoxia. Furthermore, knockdown of HO-1 suppressed the proliferation, migration and tube formation of cocultured endothelial cells. |
| PubMed ID | 23583371 |
| Year | 2013 |
| Title | Silencing heme oxygenase-1 gene expression in retinal pigment epithelial cells inhibits proliferation, migration and tube formation of cocultured endothelial cells. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.