| ncRNA name | Dll4 siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Macaca mulatta |
| Tissues/Cell_line | rhesus choroid-retinal endothelial cell line RF/6A |
| Methods | RT-PCR, qPCR, Western blot, siRNA transfection, flow cytometry, MTT assay, transwell assay, tube formation assay |
| Expression pattern | associated |
| Functional description | Knockdown of DLL4 expression significantly promoted the proliferation of hypoxic RF/6A cells and led to their arrest in the S phase of the cell cycle. Migration and tube formation of hypoxic RF/6A cells were significantly induced by the DLL4 siRNA, with the number of migrated cells increased by 1.6-fold and total tube length increased by 82.3%, compared with the scrambled siRNA. |
| PubMed ID | 21362319 |
| Year | 2011 |
| Title | Effect of DLL4 siRNA on proliferation, migration and tube formation of choroid-retinal endothelial cells under hypoxic conditions. |
| Drug-related ncRNA | NO |
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