| ncRNA name | hsa-miR-21 |
| ncRNA Category | miRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs) |
| Methods | Taqman assay, transfection, Boyden chamber migration assay, Scratch wound migration assay, BrdU incorporation assay, qRT-PCR, Western blot, luciferase reporter assay, isolectin-B4 staining |
| Expression pattern | down-regulated |
| Functional description | Our results identify miR-21 as a new angiogenesis inhibitor and suggest that inhibition of cell migration and tubulogenesis is mediated through repression of RhoB. The therapeutic potential of miR-21 as an angiogenesis inhibitor was demonstrated in vivo in a mouse model of choroidal neovascularization. |
| PubMed ID | 21347332 |
| Year | 2011 |
| Title | MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. |
| Drug-related ncRNA | NO |
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