| ncRNA name | VEGF shRNA |
| ncRNA Category | shRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human embryonic retinoblast cell line 911, human RPE cell line ARPE-19 |
| Methods | shRNA knockdown, fluorescence microscopy, qPCR, Northern blot, Western blot |
| Expression pattern | associated |
| Functional description | Potent shRNA sequences were identified that were able to silence VEGF in human RPE cells. When expressed from adenovirus backbones, these shRNA constructs silenced VEGF by 94% at a 1:5 molar ratio (VEGF to shRNA) and 64% at a 1:0.05 molar ratio. |
| PubMed ID | 16877421 |
| Year | 2006 |
| Title | Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD. |
| Drug-related ncRNA | NA |
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