| ncRNA name | CRABP-II siRNA |
| ncRNA Category | siRNA |
| Disease name | autoimmune uveitis |
| Species | Mus musculus |
| Tissues/Cell_line | RPE cells |
| Methods | flow cytometry, ELISA, microarray, qRT-PCR, siRNA transfection |
| Expression pattern | associated |
| Functional description | Our data support the hypothesis that RPE cells produce RA, thereby enabling bystander T cells to be converted into Tregs through TGFβ promotion, which can then participate in the establishment of immune tolerance in the eye. RA receptor antagonist-pretreated or RA-binding protein-siRNA-transfected RPE cells failed to convert CD4(+) T cells into Tregs. |
| PubMed ID | 22116001 |
| Year | 2012 |
| Title | Retinoic acid from retinal pigment epithelium induces T regulatory cells. |
| Drug-related ncRNA | NO |
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