| ncRNA name | RAGE siRNA |
| ncRNA Category | siRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | siRNA transfection, immunofluorescence staining, immunocytochemistry, Western blot, qPCR |
| Expression pattern | associated |
| Functional description | Receptor for advanced glycation end products (RAGE) contributed to endocytosis of Aβ in RPE. RAGE could be a potential therapeutic target for intracellular Aβ induced outer BRB breakdown in AMD. siRNA-mediated knockdown of RAGE prevented intracellular Aβ accumulation as well as subsequent tight junction breakdown in RPE. |
| PubMed ID | 26431165 |
| Year | 2015 |
| Title | RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium. |
| Drug-related ncRNA | NO |
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