| ncRNA name | hsa-miR-2964a-5p |
| ncRNA Category | miRNA |
| Disease name | age-related cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | lens epithelial cells (LECs); human lens epithelial cell line (HLEPIC); human embryonic kidney cell line (HEK-293T);human hepatoblastoma cell line (HepG2) |
| Methods | genotyping, transfection, luciferase reporter assay, qRT-PCR, Western blot, Comet assay |
| Expression pattern | associated |
| Functional description | The SNP rs4585 in ATM might affect ARC risk through modulating the regulatory affinity of miR-2964a-5p. The reduced DSBs repair might be involved in ARC pathogenesis. |
| PubMed ID | 29156695 |
| Year | 2017 |
| Title | MiR-2964a-5p binding site SNP regulates ATM expression contributing to age-related cataract risk. |
| Drug-related ncRNA | NO |
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