A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-215
ncRNA name hsa-miR-215
ncRNA Category miRNA
Disease name pterygium
Species Homo sapiens
Tissues/Cell_line pterygium tissues, normal conjunctival tissues
Methods microarray, qRT-PCR, fluorescent in situ hybridization (FISH), immunofluorescent staining, flow cytometry, luciferase reporter assay
Expression pattern down-regulated
Functional description miR-215 could play a role in inhibiting fibroblast proliferation in ocular surface conjunctiva. Dampening of this miR-215 could result in increased fibroblast cell cycling and proliferation, with possibly increased fibroblastic production of matrix, inducing pterygium formation.
PubMed ID 25565137
Year 2015
Title MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease.
Drug-related ncRNA NO

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