A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-214
ncRNA name hsa-miR-214
ncRNA Category miRNA
Disease name cataract
Species Homo sapiens
Tissues/Cell_line lens anterior capsular samples; human lens epithelial cell line SRA01/04
Methods qRT-PCR, Western blot, immunofluorescence staining, TUNEL assay, luciferase reporter assay
Expression pattern down-regulated
Functional description We demonstrated for the first time that caspase-1 is a functional downstream target of miR-214 and knockdown of KCNQ1OT1 significantly increased the expression of miR-214.
PubMed ID 28535504
Year 2017
Title Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway.
Drug-related ncRNA NO

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