A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-2113
ncRNA name hsa-miR-2113
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human Müller cell line MIO-M1
Methods qPCR, Western blot, immunouorescent staining
Expression pattern down-regulated
Functional description HG-increased MMP-2 and MMP-9 and HG-decreased TIMP-2 in Müller cells. HG up-regulates Zeb1 and lncRNA RP11-982M15.8, and down-regulates miR-2113, and Rg1 inhibits these effects of HG. Both inhibition of miR-2113 and over-expression of RP11-982M15.8 significantly restored the HG induced mesenchymal activasion.
PubMed ID 29654764
Year 2018
Title Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway.
Drug-related ncRNA YES (Ginsenoside Rg1)

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.