A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-211
ncRNA name hsa-miR-211
ncRNA Category miRNA
Disease name age-related cataract
Species Homo sapiens
Tissues/Cell_line anterior lens capsules; human epithelial cell line SRA01/04
Methods qRT-PCR, transfection, MTS assay, Western blot, luciferase reporter assay
Expression pattern up-regulated
Functional description miR-211 is highly expressed in the anterior lens capsules of patients with age-related cataracts. By negatively regulating the expression of SIRT1, miR-211 promotes lens epithelial cell apoptosis and inhibits lens epithelial cell proliferation.
PubMed ID 29487807
Year 2018
Title miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts.
Drug-related ncRNA NO

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