|diabetic retinopathy (DR)
|human retinal microvascular endothelial cells (HRMECs)
|MTT assay, wound healing assay, tube formation assay, immunofluorescence, qPCR, Western blot
|Inhibition of miR-21-5p could suppress high glucose-induced proliferation and angiogenesis of HRMECs, and these effects may partly dependent on the regulation of PI3K/AKT and ERK pathways via its target protein maspin.
|Inhibition of miR-21-5p suppresses high glucose-induced proliferation and angiogenesis of human retinal microvascular endothelial cells by the regulation of AKT and ERK pathways via maspin.
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