ncRNA name | hsa-miR-21-5p |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human retinal microvascular endothelial cells (HRMECs) |
Methods | MTT assay, wound healing assay, tube formation assay, immunofluorescence, qPCR, Western blot |
Expression pattern | up-regulated |
Functional description | Inhibition of miR-21-5p could suppress high glucose-induced proliferation and angiogenesis of HRMECs, and these effects may partly dependent on the regulation of PI3K/AKT and ERK pathways via its target protein maspin. |
PubMed ID | 29658404 |
Year | 2018 |
Title | Inhibition of miR-21-5p suppresses high glucose-induced proliferation and angiogenesis of human retinal microvascular endothelial cells by the regulation of AKT and ERK pathways via maspin. |
Drug-related ncRNA | NO |
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