|capsule samples; human embryonic kidney cell line HEK293T; human hepatoblastoma cell line HepG2
|Comet assay, qPCR, luciferase reporter assay
|The association of SNP rs2278414 with ARC might involve an altered miRNA regulation of ZNF350. The in vitro experiment indicated that miR-21-3p and miR-150-5p specifically downregulated luciferase reporter expression in the cell lines transfected with rs2278414 A allele compared with rs2278414 G.
|Functional SNP in 3'-UTR MicroRNA-Binding Site of ZNF350 Confers Risk for Age-Related Cataract.
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