A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-21
ncRNA name hsa-miR-21
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line normal uveal tissues; UM cell lines OCM-1, M619 and MuM-2B
Methods qRT-PCR, MTT assay, cell cycle assay, transwell assay, luciferase reporter assay, Western blot
Expression pattern up-regulated
Functional description Overexpression of microRNA-21 promoted proliferation, migration, and invasion of OCM-1, M619 and MuM-2B cells. Wild type p53 was identified as a target gene of microRNA-21-3p, and proved by dual luciferase reporter assay. Up-regulated microRNA-21 inhibited the expression of wild type p53 gene, and the increased expression of LASP1 in mRNA level and protein level.
PubMed ID 30140627
Year 2018
Title Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein.
Drug-related ncRNA NO

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