ncRNA name | hsa-miR-21 |
ncRNA Category | miRNA |
Disease name | retinal neovascularization |
Species | Homo sapiens |
Tissues/Cell_line | human retinal endothelial cells (HRECs) |
Methods | transfection, qRT-PCR, Western blot, angiogenesis assay |
Expression pattern | up-regulated |
Functional description | Our data show that miR-21 mediates STAT3 pro-angiogenic effects in the ischemic retina, thus suggesting its blockade as a potential therapy to prevent/halt RNV. |
PubMed ID | 29262585 |
Year | 2017 |
Title | STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.