|human retinal endothelial cells (HRECs)
|transfection, qRT-PCR, Western blot, angiogenesis assay
|Our data show that miR-21 mediates STAT3 pro-angiogenic effects in the ischemic retina, thus suggesting its blockade as a potential therapy to prevent/halt RNV.
|STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina.
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