A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-21
ncRNA name hsa-miR-21
ncRNA Category miRNA
Disease name retinal neovascularization
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs)
Methods transfection, qRT-PCR, Western blot, angiogenesis assay
Expression pattern up-regulated
Functional description Our data show that miR-21 mediates STAT3 pro-angiogenic effects in the ischemic retina, thus suggesting its blockade as a potential therapy to prevent/halt RNV.
PubMed ID 29262585
Year 2017
Title STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina.
Drug-related ncRNA NO

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