|diabetic retinopathy (DR)
|human telomerase reverse transcriptase (hTERT)– immortalized RPE cell line hTERT–RPE-1; human retinal microvascular endothelial cells (HRMECs)
|qRT-PCR, Western blot, ELISA
|Fenofibrate, a specific agonist of peroxisome proliferator-activated receptor-α (PPARα), displays robust therapeutic effects on diabetic retinopathy (DR) in patients with type 2 diabetes.miR-21 targeted PPARα by inhibiting its mRNA translation. Diabetes-induced overexpression of miR-21 in the retina is at least partly responsible for PPARα downregulation in DR. Targeting miR-21 may represent a novel therapeutic strategy for DR.
|Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα.
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