| ncRNA name | hsa-miR-21 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human telomerase reverse transcriptase (hTERT)– immortalized RPE cell line hTERT–RPE-1; human retinal microvascular endothelial cells (HRMECs) |
| Methods | qRT-PCR, Western blot, ELISA |
| Expression pattern | up-regulated |
| Functional description | Fenofibrate, a specific agonist of peroxisome proliferator-activated receptor-α (PPARα), displays robust therapeutic effects on diabetic retinopathy (DR) in patients with type 2 diabetes.miR-21 targeted PPARα by inhibiting its mRNA translation. Diabetes-induced overexpression of miR-21 in the retina is at least partly responsible for PPARα downregulation in DR. Targeting miR-21 may represent a novel therapeutic strategy for DR. |
| PubMed ID | 28270521 |
| Year | 2017 |
| Title | Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα. |
| Drug-related ncRNA | NO |
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