|granular corneal dystrophy type 2 (GCD2)
|primary corneal fibroblasts
|qRT-PCR, Western blot
|TGFBIp levels in corneal fibroblasts are controlled via the coordinated activity of miR-21 and miR-181a and by Smad signaling. Pharmacologic modulation of these miRNAs and TGF-β signaling could have therapeutic potential for TGFBI-associated corneal dystrophy, including GCD2.
|TGF-β regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling.
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.