A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-21
ncRNA name hsa-miR-21
ncRNA Category miRNA
Disease name Behcet's disease (BD)
Species Homo sapiens
Tissues/Cell_line peripheral blood mononuclear cells (PBMCs)
Methods RT-PCR, qPCR, flow cytometry, ELISA
Expression pattern up-regulated
Functional description miR-21 was correlated with HSV-induced BD-like inflammation in mice and BD patients. The expression of miR-21 was regulated by antagomir in mice. Treatment with colchicine or pentoxifylline down-regulated the level of miR-21 with improved symptoms in mice.
PubMed ID 25849652
Year 2015
Title The relevance of miRNA-21 in HSV-induced inflammation in a mouse model.
Drug-related ncRNA YES (colchicine, pentoxifylline)

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