|age-related macular degeneration (AMD)
|human RPE cell line ARPE-19
|qRT-PCR, transfection, luciferase reporter assay, immunoblot, immunofluorescence, immunoprecipitation
|The inhibition of miR-184 decreased EZR-bound LAMP-1 protein levels and affected phagocytic activity in ARPE19 cells. Downregulation of miR-184 was consistent with significantly lower levels of LAMP-1 protein in AMD RPE, and overexpression of miR-184 in AMD RPE was able to rescue LAMP-1 protein expression to normal levels.
|miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration.
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