A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-184
ncRNA name hsa-miR-184
ncRNA Category miRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods qRT-PCR, transfection, luciferase reporter assay, immunoblot, immunofluorescence, immunoprecipitation
Expression pattern down-regulated
Functional description The inhibition of miR-184 decreased EZR-bound LAMP-1 protein levels and affected phagocytic activity in ARPE19 cells. Downregulation of miR-184 was consistent with significantly lower levels of LAMP-1 protein in AMD RPE, and overexpression of miR-184 in AMD RPE was able to rescue LAMP-1 protein expression to normal levels.
PubMed ID 25251993
Year 2014
Title miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration.
Drug-related ncRNA NO

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