| ncRNA name | hsa-miR-184 |
| ncRNA Category | miRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | qRT-PCR, transfection, luciferase reporter assay, immunoblot, immunofluorescence, immunoprecipitation |
| Expression pattern | down-regulated |
| Functional description | The inhibition of miR-184 decreased EZR-bound LAMP-1 protein levels and affected phagocytic activity in ARPE19 cells. Downregulation of miR-184 was consistent with significantly lower levels of LAMP-1 protein in AMD RPE, and overexpression of miR-184 in AMD RPE was able to rescue LAMP-1 protein expression to normal levels. |
| PubMed ID | 25251993 |
| Year | 2014 |
| Title | miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration. |
| Drug-related ncRNA | NO |
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