| ncRNA name | hsa-miR-184 |
| ncRNA Category | miRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | hiPSC-RPE, human RPE cell line ARPE-19 |
| Methods | RT-PCR, immunofluorescence, transfection, luciferase reporter assay, immunoblot |
| Expression pattern | down-regulated |
| Functional description | miR-184 insufficiency is involved in the pathogenesis of dry AMD. miR-184 promotes RPE differentiation via inhibiting the AKT2/mTOR signaling pathway. miR-184 based supplementary therapeutics and mTOR blocker, like rapamycin, are prospective options for AMD treatment. |
| PubMed ID | 27418134 |
| Year | 2016 |
| Title | MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway. |
| Drug-related ncRNA | YES (rapamycin) |
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