A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-184
ncRNA name hsa-miR-184
ncRNA Category miRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line hiPSC-RPE, human RPE cell line ARPE-19
Methods RT-PCR, immunofluorescence, transfection, luciferase reporter assay, immunoblot
Expression pattern down-regulated
Functional description miR-184 insufficiency is involved in the pathogenesis of dry AMD. miR-184 promotes RPE differentiation via inhibiting the AKT2/mTOR signaling pathway. miR-184 based supplementary therapeutics and mTOR blocker, like rapamycin, are prospective options for AMD treatment.
PubMed ID 27418134
Year 2016
Title MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway.
Drug-related ncRNA YES (rapamycin)

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