|proliferative vitreoretinopathy (PVR)
|RPE cells; human embryonic kidney cell line HEK-293
|qRT-PCR, flow cytometry, transwell assay, luciferase reporter assay, Western blot
|Transfection of miR-182 into RPE cells induced c-Met downregulation, which led to reduced cell proliferation and migration through declines in p-Akt formation. miR-182 downregulation along with c-Met upregulation in PVR tissues suggest that these two opposing effects play important roles in PVR development.
|MicroRNA-182 Suppresses HGF/SF-Induced Increases in Retinal Pigment Epithelial Cell Proliferation and Migration through Targeting c-Met.
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