| ncRNA name | hsa-miR-182 |
| ncRNA Category | miRNA |
| Disease name | proliferative vitreoretinopathy (PVR) |
| Species | Homo sapiens |
| Tissues/Cell_line | RPE cells; human embryonic kidney cell line HEK-293 |
| Methods | qRT-PCR, flow cytometry, transwell assay, luciferase reporter assay, Western blot |
| Expression pattern | down-regulated |
| Functional description | Transfection of miR-182 into RPE cells induced c-Met downregulation, which led to reduced cell proliferation and migration through declines in p-Akt formation. miR-182 downregulation along with c-Met upregulation in PVR tissues suggest that these two opposing effects play important roles in PVR development. |
| PubMed ID | 27936052 |
| Year | 2016 |
| Title | MicroRNA-182 Suppresses HGF/SF-Induced Increases in Retinal Pigment Epithelial Cell Proliferation and Migration through Targeting c-Met. |
| Drug-related ncRNA | NO |
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