|uveal melanoma (UM)
|human UM cell lines M23 and SP6.5; human embryonic kidney cell line HEK-293; UM samples, normal uveal tissues
|qRT-PCR, flow cytometry, transwell assay, Matrigel invasion assay, Hoechst staining, Caspase activity assay, luciferase reporter assay, Western blot, tumor growth assay
|miR-182, a p53 dependent miRNA, suppressed the expression of MITF, BCL2, cyclin D2 and functioned as a potent tumor suppressor in uveal melanoma cells.
|Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2.
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