A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-155
ncRNA name hsa-miR-155
ncRNA Category miRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human neocortical and retinal samples
Methods miRNA sequencing, miRNA array
Expression pattern up-regulated
Functional description We report the sequence and abundance of a septet of sncRNAs that are significantly increased in abundance and common to both AD-affected superior temporal lobe neocortex and the AMD-affected macular region of the retina. Their target mRNAs are involved in the synchronization of amyloid production and clearance, phagocytosis, innate-immune, pro-inflammatory, and neurotrophic signaling and/or synaptogenesis.
PubMed ID 29302837
Year 2018
Title Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD).
Drug-related ncRNA NO

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