ncRNA name | hsa-miR-155 |
ncRNA Category | miRNA |
Disease name | Pseudomonas aeruginosa keratitis |
Species | Homo sapiens |
Tissues/Cell_line | corneas |
Methods | qPCR, transfection, flow cytometry, Western blot |
Expression pattern | up-regulated |
Functional description | miR-155 suppressed the macrophage-mediated bacterial phagocytosis and intracellular killing of P. aeruginosa by targeting Rheb (Ras homolog enriched in brain). miR-155 knockout mice displayed more resistance to P. aeruginosa keratitis. |
PubMed ID | 24403554 |
Year | 2014 |
Title | miR-155 suppresses bacterial clearance in Pseudomonas aeruginosa-induced keratitis by targeting Rheb. |
Drug-related ncRNA | NO |
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