A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a-5p
ncRNA name hsa-miR-146a-5p
ncRNA Category miRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line retinas, vitreous
Methods RNA-seq, immunoprecipitation, reporter assay, qPCR
Expression pattern up-regulated
Functional description Two variants (rs766666504 and rs459598) existed in DNA sequence encoding the seed region of hsa-miR-146a-5p in the CFH mRNA 3' UTR - as this miRNA is also elevated in both vitreous and serum of people with AAMD, it shows great value as a biomarker.
PubMed ID 28343170
Year 2017
Title miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD).
Drug-related ncRNA NO

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