A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a-5p
ncRNA name hsa-miR-146a-5p
ncRNA Category miRNA
Disease name conjunctival melanoma
Species Homo sapiens
Tissues/Cell_line conjunctival malignant melanoma samples, normal conjunctivas
Methods microarray
Expression pattern up-regulated
Functional description MicroRNA expression analysis revealed 25 tumour-specific microRNAs in conjunctival melanoma. Five possibly oncogenic miRNAs (miR-20b-5p, miR-146b-5p, miR-146a-5p, miR-506-3p and miR-509-3p) were up-regulated. Seven microRNAs (miR-30d-5p, miR-138-5p, miR-146a-5p, miR-500a-5p, miR-501-3p, miR-501-5p and miR-502-3p) were significantly and simultaneously up-regulated in both stage T1 and stage T2 tumours, and were associated with increased tumour thickness.
PubMed ID 27192168
Year 2016
Title Conjunctival malignant melanoma in Denmark: epidemiology, treatment and prognosis with special emphasis on tumorigenesis and genetic profile.
Drug-related ncRNA NO

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