A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a-5p
ncRNA name hsa-miR-146a-5p
ncRNA Category miRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line vitreous humour, blood
Methods microarray, qPCR
Expression pattern up-regulated
Functional description We identified a disease-associated increase in miR-146a and a decrease in miR-106b and miR-152 in the vitreous humour which was reproducible in plasma. Moreover, miR-146a/miR-106b ratios discriminated patients with NV AMD with an area under the Receiver Operating Characteristic curve (ROC AUC) of 0,977 in vitreous humour and 0,915 in plasma suggesting potential for a blood-based diagnostic.
PubMed ID 27015561
Year 2016
Title MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD.
Drug-related ncRNA NO

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