A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a-5p
ncRNA name hsa-miR-146a-5p
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal microvascular endothelial cells
Methods transfection, qPCR, Western blot, ELISA
Expression pattern down-regulated
Functional description The results suggest that miR-146a is a potential therapeutic target for reducing inflammation in REC through inhibition of TLR4/NF-κB and TNFα.
PubMed ID 26997759
Year 2016
Title miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose.
Drug-related ncRNA NO

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