A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a
ncRNA name hsa-miR-146a
ncRNA Category miRNA
Disease name Graves ophthalmopathy
Species Homo sapiens
Tissues/Cell_line blood, orbital connective tissue
Methods immunofluorescence, qRT-PCR, luciferase reporter assay, transfection, Western blot, MTT assay, flow cytometry, ELISA
Expression pattern up-regulated
Functional description MicroRNA-146a may increase the IL-6 levels and exacerbate GO by directly targeting Notch2.The over-expression of miR-146a markedly facilitated Orbital Fibroblasts (OFs) viability and mitosis whereas markedly suppressed cell apoptosis
PubMed ID 28278511
Year 2017
Title Mechanism of MicroRNA-146a/Notch2 Signaling Regulating IL-6 in Graves Ophthalmopathy.
Drug-related ncRNA NO

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