|blood, orbital connective tissue
|immunofluorescence, qRT-PCR, luciferase reporter assay, transfection, Western blot, MTT assay, flow cytometry, ELISA
|MicroRNA-146a may increase the IL-6 levels and exacerbate GO by directly targeting Notch2.The over-expression of miR-146a markedly facilitated Orbital Fibroblasts (OFs) viability and mitosis whereas markedly suppressed cell apoptosis
|Mechanism of MicroRNA-146a/Notch2 Signaling Regulating IL-6 in Graves Ophthalmopathy.
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