A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a
ncRNA name hsa-miR-146a
ncRNA Category miRNA
Disease name diabetic keratopathy
Species Homo sapiens
Tissues/Cell_line corneas; human corneal epithelial cells (HCECs)
Methods microarray, qRT-PCR, in situ hybridization, transfection, Western blot, immunocytochemistry
Expression pattern up-regulated
Functional description HCEC transfection with h-miR-146a or h-miR-424 significantly retarded wound closure. Cells treated with h-miR-146a or h-miR-424 had decreased p-p38 and p-EGFR staining. Functional roles: Inflammatory responses, hematopoiesis, migration and proliferation.
PubMed ID 24376808
Year 2013
Title Differentially expressed wound healing-related microRNAs in the human diabetic cornea.
Drug-related ncRNA NO

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