ncRNA name | hsa-miR-146a |
ncRNA Category | miRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Homo sapiens |
Tissues/Cell_line | retinas |
Methods | RT-PCR, Northern blot |
Expression pattern | up-regulated |
Functional description | miR-9, miR-125b, miR-146a and miR-155 are progressively up-regulated in both AD and AMD. This quartet of up-regulated miRNAs in turn down-regulate a small brain- and retinal-cell-relevant family of target mRNAs, including that encoding complement factor H (CFH), a major negative regulator of the innate immune and inflammatory response. |
PubMed ID | 22509485 |
Year | 2012 |
Title | Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD). |
Drug-related ncRNA | NO |
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