A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a
ncRNA name hsa-miR-146a
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human umbilical-vein endothelial cells (HUVECs)
Methods transfection, RT-PCR, ELISA, luciferase reporter assay
Expression pattern down-regulated
Functional description A total of 25 mmol/L glucose decreased miR-146a expression and increased FN expression compared with 5 mmol/L glucose in both cell types. miR-146a mimic transfection prevented such change, whereas miR-146a antagomir transfection in the cells in 5 mmol/L glucose caused FN upregulation.
PubMed ID 21885871
Year 2011
Title miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications.
Drug-related ncRNA NO

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