|diabetic retinopathy (DR)
|human umbilical-vein endothelial cells (HUVECs)
|transfection, RT-PCR, ELISA, luciferase reporter assay
|A total of 25 mmol/L glucose decreased miR-146a expression and increased FN expression compared with 5 mmol/L glucose in both cell types. miR-146a mimic transfection prevented such change, whereas miR-146a antagomir transfection in the cells in 5 mmol/L glucose caused FN upregulation.
|miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications.
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