A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-146a
ncRNA name hsa-miR-146a
ncRNA Category miRNA
Disease name primary Sjögren's syndrome (pSS)
Species Homo sapiens
Tissues/Cell_line peripheral blood mononuclear cells (PBMCs); human monocytes line THP-1
Methods qRT-PCR, in situ hybridization, transfection, flow cytometry, transwell assay
Expression pattern up-regulated
Functional description Functional analysis revealed roles for miR-146a in increasing phagocytic activity and suppressing inflammatory cytokine production while migration, nitric oxide production and expression of antigen-presenting/costimulatory molecules are not affected in human monocytic THP-1 cells.
PubMed ID 21469088
Year 2011
Title Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity.
Drug-related ncRNA NO

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