|primary Sjögren's syndrome (pSS)
|peripheral blood mononuclear cells (PBMCs); human monocytes line THP-1
|qRT-PCR, in situ hybridization, transfection, flow cytometry, transwell assay
|Functional analysis revealed roles for miR-146a in increasing phagocytic activity and suppressing inflammatory cytokine production while migration, nitric oxide production and expression of antigen-presenting/costimulatory molecules are not affected in human monocytic THP-1 cells.
|Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity.
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